3D CELL-BASED ASSAYS

 

NEW BREAKTHROUGH READ-OUTS

 

HTS/HCS COMPATIBLE

 

oncology

CANCER RESEARCH

Cell mechanics or cell organization are key parameters for cancer development and metastasis.

The FMPsTM enable us to better control these parameters and offer new read-outs to decipher cancer progression and invasiveness. For instance, spindle assembly disorders of cancerous cells are easily assessed via FMPsTM Cell confinement technology.

immunology

IMMUNOLOGY

Sensing and migration in the tissues is the basis of the immune system functionning.

FMPsTM are the best tools to quantitfy immune activities such as cell migration, cell-interaction, nucleus plasticity, among others. For instance, FMPsTMMicrochannels can quantify leukocyte extravasation ability, with read-outs such as: cell speed, persistence and ability to pass through constricted spaces.

line patterned cardiomyocytes

ORGAN PHYSIOLOGY

The regular physiology of cells in living organs is closely linked with its spatial and mechanical organization.

FMPsTM offer simple and representative models highlighting organ specific read-outs. For instance, FMPsTM Micropatterns induce striation of cardiomyocyte leading to standardized beating properties and internal organization.

rare disease

RARE DISEASES

Rare diseases are often linked to cell mechanics or cell organization disorders.

The FMPsTM highlight alterations like these and one can measure molecular modifications more easily than with other models. For instance, cell nucleus healing in laminopathy is evaluated using FMPsTM Cell confinement by the observation of lamina reconstruction as a read-out.

 

CHOOSE YOUR APPLICATION

 

immunology

FMP

Study immune cell migration, cell-cell communication, antigene searching, intracellular organization.
rare disease

FMP

Study laminopathy, neurosciences, nucleus integrity.
organ physiology

FMP

Study tissue mechanics, wound healing, organoids, cell trafficking, polarity, division, internal organization.
cancer

FMP

Study cancer cell invasion, genomic instability, cell proliferation.
scientipole wilco

4Dcell is one of the 2018 laureates of the most important french scientific entrepreneur network.
Scientipole is partner in 4Dcell success with a loan to achieve the first operational prototype of the new generation of multiwell plates for 3D cell culture.

iLAB

4Dcell was also nominated for the 2018 national competition for innovative technologies company creation.

THEY TRUST US