Applications

4Dcell provides tutorials, reviews and publications on topics related to 3D cell culture and biophysics. The aim of this section is to provide information to beginners and confirmed researchers in biology to help them explore easily this field.

4Dcell products can be used for a wide range of applications. Discover some of them!

 

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General reviews and application notes about advanced cell cultures technologies:

 

cell confined

APPLICATION NOTE – CELL CONFINEMENT, A STEP CLOSER INTO IN VIVO CELL MIGRATION

Cell migration plays an extremely important role in the dynamics of biological systems, ranging from unicellular to complex multi-cellular ones. In this particular case, such technology enabled the validation of a universal model … READ MORE

micropatterned cardiomyocyotes

APPLICATION NOTE – MIMIC THE CARDIAC MUSCLE CONTRACTION USING MICROPATTERNS

By implementing standardized line-micropatterns, the goal is to force the cells to grow in a stripe configuration and study their individual behavior and as a whole. The purpose is to get closer to the real cardiac muscle … READ MORE

microchannels migration

APPLICATION NOTE – STUDY IMMUNE CELL MIGRATION USING MICROCHANNELS

This simplified migration, restricted directionality, facilitates the automatic tracking of cells and the extraction of quantitative parameters to describe cell movementREAD MORE

micropatterned cells

APPLICATION NOTE – CELL MIGRATION DIRECTED BY MICROPATTERNED PROTEIN SUBSTRATES

Nowadays micro-engineering techniques help to mimic the cell microenvironment by manipulating the cell culture conditions. Micropatterns can provide a dynamic, complex and micrometer-scale habitat as well as a good observation of the cell migration… READ MORE

Make your neurons happier

REVIEW – MAKE YOUR NEURONS HAPPIER!

Control, guide and evaluate outgrowth of neuronal culture

Neurons are often cultured in vitro on a flat, open, and rigid substrate, a platform that does not reflect well the native microenvironment of the brain. The cell’s microenvironment is defined by … READ MORE

Neurons

APPLICATION NOTE – NEURAL TISSUE ENGINEERING

Matrix stiffness modulates formation and activity of neuronal networks

Mechanical properties of the culture matrix can modulate important neuronal functions such as growth, extension, branching and activity. Microprinted neuronal networks was … READ MORE

Cell Confiner - Pack microscope

REVIEW – CELL CONFINEMENT

3D Cell Culture & Cell Confinement

The problems of dissimilarity between 2D cell culture and a cell’s natural environment have become evident after numerous studies demonstrated that the cellular microenvironment  … READ MORE

4Dcell micropatterning quartz

REVIEW – MICROPATTERNING

Revolutionizing cell culture by implementing adhesive micropatterns to control the microenvironment

The problems of dissimilarity between 2D cell culture and a cell’s natural environment have become evident after numerous studies demonstrated that the cellular microenvironment  … READ MORE

Microchannels on chip on petri dish 4DCell

REVIEW – MICROCHANNELS

Discovering 3D cell culture through a modern microfluidic device, the microchannels

Cells in the body are physically confined by neighboring cells, tissues, and the extracellular matrix. Then, the microenvironment surrounding a cell significantly influences … READ MORE