4Dcell provides tutorials, reviews and publications on topics related to 3D cell culture, high content screening, high content imaging and biophysics. The aim of this section is to provide information to beginners and confirmed researchers in biology to help them explore easily this field.
4Dcell products can be used for a wide range of applications. Discover some of them!
General reviews and application notes about advanced cell cultures technologies:
APPLICATION NOTE – CELL CONFINEMENT, A STEP CLOSER INTO IN VIVO CELL MIGRATION
Cell migration plays an extremely important role in the dynamics of biological systems, ranging from unicellular to complex multi-cellular ones. In this particular case, such technology enabled the validation of a universal model … READ MORE
APPLICATION NOTE – MIMIC THE CARDIAC MUSCLE CONTRACTION USING MICROPATTERNS
By implementing standardized line-micropatterns, the goal is to force the cells to grow in a stripe configuration and study their individual behavior and as a whole. The purpose is to get closer to the real cardiac muscle … READ MORE
APPLICATION NOTE – STUDY IMMUNE CELL MIGRATION USING MICROCHANNELS
Immune cell migration in vitro testing in microchannels
This simplified migration, restricted directionality, facilitates the automatic tracking of cells and the extraction of quantitative parameters to describe cell movement. READ MORE
APPLICATION NOTE – CELL MIGRATION DIRECTED BY MICROPATTERNED PROTEIN SUBSTRATES
In vitro assays for cell migration on micropatterned substrates
Nowadays micro-engineering techniques help to mimic the cell microenvironment by manipulating the cell culture conditions. Micropatterns can provide a dynamic, complex and micrometer-scale habitat as well as a good observation of the cell migration… READ MORE
REVIEW – MAKE YOUR NEURONS HAPPIER!
Control, guide and evaluate outgrowth of neuronal culture
Neurons are often cultured in vitro on a flat, open, and rigid substrate, a platform that does not reflect well the native microenvironment of the brain. The cell’s microenvironment is defined by … READ MORE
APPLICATION NOTE – NEURAL TISSUE ENGINEERING
Matrix stiffness modulates formation and activity of neuronal networks
Mechanical properties of the culture matrix can modulate important neuronal functions such as growth, extension, branching and activity. Microprinted neuronal networks was … READ MORE
3D Cell Culture & Cell Confinement
The problems of dissimilarity between 2D cell culture and a cell’s natural environment have become evident after numerous studies demonstrated that the cellular microenvironment … READ MORE
Revolutionizing cell culture by implementing adhesive micropatterns to control the microenvironment
The problems of dissimilarity between 2D cell culture and a cell’s natural environment have become evident after numerous studies demonstrated that the cellular microenvironment … READ MORE
Discovering 3D cell culture through a modern microfluidic device, the microchannels
Cells in the body are physically confined by neighboring cells, tissues, and the extracellular matrix. Then, the microenvironment surrounding a cell significantly influences … READ MORE