NEW BREAKTHROUGH READ-OUTS FOR ORGAN MIMICKING

3D CELL-BASED ASSAYS FOR HTS/HCS

  • HIGH STANDARDIZATION FOR SCREENING ASSAYS

  • null

    FULLY COMPATIBLE WITH HIGH RESOLUTION IMAGING

  • COMPATIBLE WITH INDUSTRIAL PROCESS (SBS FORMAT)

Organ on chip

ORGAN PHYSIOLOGY

micropatterned cardiomyocyotes

hPSC-CM on line micropatterns imaged by fluorescence microscopy.
Dussaud S., Jouve C., Hulot J.S., 2018, INSERM, PARCC.

The regular physiology of cells in living organs is closely linked with its spatial and mechanical organization.

FMPsTM offer simple and representative models highlighting organ specific read-outs. For instance, FMPsTM Micropatterns induce striation of cardiomyocyte leading to standardized beating properties and internal organization.

Principle of the micropatterning technology for cell standardization:
micropatterning

The role of 4Dcell’s novel multi-well plates is to provide in HTS/HCS platforms new models that better predict and quantify, in vitro, the in vivo behavior of cells.

Besides from the micropatterns integrated into 96-well plates, 4Dcell also provides micropatterned single slides.