MICROCHANNELS DISH

Let’s guide your cells

iBMD cells migrating within microchannels.
Réf. video by 4Dcell partner Dr Pablo Vargas, Curie Institute/UMR144

  • Ready to use

    All you need is a pipette to load your cells.

  • Large range of sizes available

    From 3 to 1000 µm width, adapted to single cell or collective migration.

  • High quality live imaging

    Glass bottom petri dish to reduce microscope working distance.

The PDMS microchannels are already binded to the 35 mm glass bottom petri dish.

Just rinse the microchannels, add some extracellular matrix protein and load your cells !

Microchannels’ Dimensions

The 3D shape and stress conditions imposed to your cells depend on the microchannels size. Each chip has 6 ranges of microchannels and 9 access ports.

microchannels designs
small microchannels cell migration

Small microchannels chip design available in different heights (MC001, MC002, MC003, MC004).

medium microchannels cell migration

Medium microchannels chip design (MC005)

4Dcell also provides microchannels with constrictions, with the following sizes:

constriction microchannels
constriction microchannels

Example of a 4Dcell microchannel with a constriction of 1.5 µm width.

The Microchannels provide a wide range of applications:

CANCER

  • Migration of metastatic cells
  • Nuclear plasicity in mestastasis
  • DNA DSB repair (mechanically induced)
  • Angiogenesis
  • Immuno-oncology

 

IMMUNOLOGY

  • Cell-cell interaction
  • Migration of immune cells
  • Antigene searching
  • Extravasation/diapedesis
  • Chemotaxis/haptotaxis

 

ORGAN PHYSIOLOGY

  • Migration of cancer cells
  • Shear stress
  • Angiogenesis
  • Epithelium permeability/brain blood barrier
  • Neural network

 

RARE DISEASES

  • Cell nucleus integrity
  • Nuclear plasticity
  • Neural network

 

FUNDAMENTAL RESEARCH

  • Cell adhesion

Example of iBMD Cells migrating within microchannels of different sizes (0.5 image/min)
Réf. video by 4Dcell partner Dr Pablo Vargas, Curie Institute/UMR144