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5000+ ORGANOIDS

5000+ ORGANOIDS

5000+ ORGANOIDS

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HYDROGELS
TUNE THE STIFFNESS OF THE CULTURE SUBSTRATE

GUIDING CELLULAR BEHAVIOR WITH PRECISION

Hydrogels are a cornerstone of in vitro cell culture, providing a tunable microenvironment that mimics the mechanical properties of native tissues.

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The 4Dcell offering includes two hydrogel-coated coverslip formats that integrate seamlessly with your microscopy workflows.

The first, a simple hydrogel coverslip, pairs a glass substrate with a biocompatible matrix whose elasticity can be adjusted from a few hundred pascals to several kilopascals, perfect for probing cell adhesion, motility, and differentiation as a function of substrate stiffness.

The second, a microstructured hydrogel coverslip, retains this mechanical tunability while adding customizable microgrooves: these microscopic channels guide and align cells (neuronal axons, muscle fibers, dendrites…), control their polarization, and promote the formation of structured endothelial networks, delivering a more faithful reproduction of in vivo tissue architectures.

 

Together, these two products provide a highly reproducible, easy-to-implement platform that combines mechanical and topographical cues to accelerate your discoveries and enhance the robustness of your results.

Easy to use

High resolution imaging

Long term cell culture

PLATE YOUR CELLS. LET THEM GROW. MEASURE.

HYDROGEL TECHNOLOGY

Cells are cultured in a 3D environment (different stiffnesses, either flat or microstructured, to mimic in vivo conditions).

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  • Stiffness of the substrate can be chosen from very soft (1 kPa) to very hard (50 kPa)

  • Wide range of substrates topography available (flat, round wells, square wells, grooves, etc.)

  • The gel based substrates are ready to be used in your cell culture experiments 

  • Easy and straightforward to use, since cells are seeded directly on top of the features (convenient to confine non migrating cells)

  • Pre-coated with ECM matrix (e.g. fibronectin) 

  • Adaptable to any cell culture substrate (coverslips, Petri dishes, multiwell plates)

  • The optically transparency of the gels makes these substrates compatible with high-resolution optical microscopy systems

 

Contact us if you want a customized design.

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Gel on coverslip principle

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Microstructured gel principle

SMARTGELS APPLICATIONS

Cell differentiation, Cell mechanics, Cell contractility, Cell migration, Tissue geometry mimicry, 3D cell shape control, etc.

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HeLa cells seeded on microstructured gels

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Mouse embryonic fibroblasts seeded on grooves 

Domains of application

CANCER​

  • Cell shape standardization

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ORGAN PHYSIOLOGY​

  • Migration of somatic and cancer cells

  • Cell shape standardization

  • Cardiomyocyte beating properties

  • Neural network

  • Detection of bile canaliculi in hepatocytes

  • Tissue geometry mimicry​

​RARE DISEASES

  • Cell nucleus integrity

  • Nuclear plasticity

  • Neural network

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FUNDAMENTAL RESEARCH

  • Cell shape standardization

  • Standardized connectivity between neurons

 

BIOMOLECULAR IN VITRO MODELS

  • Spatial autoorganization of macromolecules (at the microscale)

SMARTGELS CATALOG

YOU WANT TO PUSH THE LIMITS OF 3D CELL CULTURE? LET'S DISCUSS YOUR PROJECTS

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