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TECHNOLOGY OF PRECISION
LATEST GENERATION OF 3D CELL CULTURE PLATES
DESIGNED FOR CONTRACTILE TISSUES.
CONTRACTILE ASSAY
Our multidisciplinary team of experts developed the SmartContractility® technology aiming to create a robust bioengineered platform for easy and efficient contractile tissue culture.
Designed specifically for heart and skeletal muscle tissues, our system requires minimal handling, uses only a small number of cells, and forms tissues quickly with strong reproducibility across wells, with each assay rigorously standardized by employing several replicates per well.
With in situ characterization capabilities and a glass bottom on each plate, our platform ensures high-resolution imaging, allowing detailed analysis and verification of contractility parameters every step of the way.
PLATE YOUR CELLS. LET THEM BEAT. MEASURE.
Easy to use
High Throughput
Low amount of cells
High resolution imaging
In situ characterization
Long term cell culture
Proprietary well design
Cells are seeded on substrates coated with a 3D structured hydrogel molded into conical-shaped microwells with a central pillar. As cells settle on these microstructures, they self-organize into circular tissues encircling the pillar.
The deformation of the pillar, provides measurements of contractility force, beating rate, and amplitude, etc.
The engineered shape and contact area of the pillar help secure the tissues in place.
SmartContractility® Technology applied to cardiac models
AI Analizer - SmartX® 2.0
Bright field videos (e.g. 500x500 pixels, min 35 fps and 10 s length) of the contracting rings can be analyzed using SmartX 2.0.
The algorithm uses machine learning to detect and track the area of the central pilar, from which it determines several parameters: contraction amplitude, contraction strain, contraction and relaxation speed, contraction stress, etc.
Automation driven
4Dcell's R&D team designed the SmartContractility solution to be compatible with current industrial automated platforms, adhering to SLAS/ANSI standards.
We engineered commercial plates that you already use in your routine automated experiments. This was the first step in our development journey to make your lab work significantly easier.
Explore the powerful insights and depth of information offered by the 4Dcell cardiac platform
YOU WANT TO PUSH THE LIMITS OF 3D CELL CULTURE? LET'S DISCUSS YOUR PROJECTS
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