3D cell culture platform to design organ and disease models.
KEY PRODUCTS
3D, “2.5D” and 2D bioengineered cell culture consumables to control the cell microenvironment, and create innovative and perfectly adapted cell models.
4Dcell is a pioneer in the development and commercialization of microfabricated systems dedicated to the control of the cell microenvironment. With hundreds of customers around the globe, we answered many specific requests about all kinds of cell types and applications. With this strong expertise, 4Dcell solutions allow you to develop reproductible and robust cell models to design the perfect assay.
Self assembly of cell aggregates with a ring shape that that facilitate contractility force measurements
Hydrogel based microwells to form functional and reproducible spheroids. An anchoring point precludes them from being lost during medium exchange.
Homogenous confinement of cells between two parallel planes to a defined micrometer height with sub micrometer resolution.
APPLICATIONS
A widespread range of applications for 4Dcell 2D and ”2.5D” tools, covering the hot topics of the moment in cell biology. 4Dcell technologies can be applied to several cell types and enable the acquisition of distinct readouts.
BY CELL TYPE
Immune cells
Improve tracking and imaging of immune cells, imitate phagocytosis and improve the phenotypes of your cells
Cardiomyocytes
Improve differentiation of neonatal and iPSC-derived cardiomyocytes, quantify contractility
Muscle cells
Improve differentiation of myoblasts to myotubes, quantify contractility and imitate the neuromuscular junction
Hepatocytes
Improve cell-cell interaction and imaging
Neurons
Improve neuronal network formation and imitate the neuromuscular junction
Cancer cells
Observe cancer cell migration in conditions that imitate metastasis, and quantify aggressiveness and contractility
Fibroblasts
Trigger migration using click chemistry, quantify cell contractility
Stem cells
Manipulate stem cell differentiation using cell patterning and substrate stiffness
Other cell types
Assays for bone cells, adipocytes, endothelial cells, ciliated cells, and other general applications
BY READOUT
Cell migration
Confine migration in 2D or 3D to facilitate tracking, mimic migration through tissues, and study chemotaxis
Cell organization & phenotype
Restrict cell adhesion in 2D to promote differentiation or improve reproducibility of your assays
Cell differentiation
Drive cell differentiation by controlling substrate stiffness and confining cells in 2D and 3D
Cell-cell interaction
Confine your cells in 2D to better image interaction between one or more cell type
Cell contractility
Quantify the contractility of cells on gels or micropillars
Cell membrane events
Mimic phagocytosis, Observe endo- or exocytosis, and generate exosomes
Mitosis & nucleus related events
Quantify nucleus fragility and the ability of the cell to perform mitosis under stress
Co-cultures
Analysis of the cell-cell contact by click chemistry technology
Cell volume
Accurately measure the volume of your cells
Other readouts
Spheroid formation, blood vessel formation, neuromuscular junction and more
THEY TRUST US
