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5000+ ORGANOIDS

5000+ ORGANOIDS

5000+ ORGANOIDS

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SMARTPILLARS
DEFINE THE CONTRACTILE FORCE OF YOUR CELLS

PRECISION MECHANOBIOLOGY WITH MICROPILLAR ARRAYS

Micropillar technology from 4Dcell harnesses arrays of vertical, elastic microstructures to transform cellular forces into precise, quantifiable deflections. Each coverslip features a uniform grid of silicone pillars whose height, diameter, and spacing you can tailor to match tissue-specific mechanics? enabling real-time measurement of traction forces, migration dynamics, and contractility at the single-cell level.

 

Seamlessly compatible with live-cell imaging and high-throughput screening, our micropillar platforms provide a turnkey solution for probing mechanotransduction, drug responses, and cell, matrix interactions with unprecedented sensitivity and reproducibility.

 

Whether you’re mapping cardiomyocyte contractions, studying cancer cell invasion, or dissecting fibroblast remodeling, 4Dcell’s micropillars deliver the mechanical cues and readouts you need to accelerate your mechanobiology research.

Easy to use

High resolution imaging

Long term cell culture

PLATE YOUR CELLS. LET'S THEM CONTRACT. MEASURE.

MICROPILLAR TECHNOLOGY

Cells are cultured on substrates containing topographic features, micropillars, with a specific stiffness. The micropillars can either be distributed in high density to create a map of the force applied by the cell (Traction force microscopy) or their size and arrangement can be of cell size thus being useful to measure the global contractile force of a single cell.

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  • The deflection of PDMS pillars enables force sensing

  • The stiffness of the PDMS micropillars is controlled by their size (Durotaxis)

  • Several micropillars geometries and arrangements available

  • Single cell force mapping (Traction Force Microscopy)

  • Controllable bio-functionalization

  • Available on 35 mm Petri dishes 

  • Compatible with high-resolution optical microscopy systems

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SMARTPILLARS APPLICATIONS

Force sensing, migration assays with substrate stiffness control (durotaxis), Traction Force Microscopy, etc

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Fibroblast on substrate with micropillars (Léa Trichet et al. PNAS, 109 (18), 2012). 

Domains of application

CANCER​

  • Cell shape standardization

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FUNDAMENTAL RESEARCH

  • Durotaxis

  • Traction Force Microscopy 

  • Contractility Force assessment 

ORGAN PHYSIOLOGY

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  • Migration of somatic and cancer cells

  • Cell shape standardization

  • Cardiomyocyte beating properties​

SMARTPILLARS CATALOG

YOU WANT TO PUSH THE LIMITS OF 3D CELL CULTURE? LET'S DISCUSS YOUR PROJECTS

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