2D and “2.5D” bioengineered cell culture consumables to control the cell microenvironment
4Dcell is a pioneer in the development and commercialization of microfabricated systems dedicated to the control of the cell microenvironment.
Homogenous confinement of cells between two parallel planes to a defined micrometer height with sub micrometer resolution.
Microfluidic devices to study cell migration under controlled conditions mimicking their physiological environment.
EXAMPLES OF APPLICATIONS
> CANCER RESEARCH
Cell mechanics or cell organization are key parameters for cancer development and metastasis.
4Dcell enables better control of these parameters and offer new read-outs to decipher cancer progression and invasiveness.
For instance, spindle assembly disorders of cancerous cells are easily assessed via Cell confinement technology.
Sensing and migration in the tissues is the basis of the immune system functionning.
4Dcell technologies are the best tools to quantitfy immune activities such as cell migration, cell-interaction, nucleus plasticity, among others.
For instance, 4Dcell Microchannels can quantify leukocyte extravasation ability, with read-outs such as: cell speed, persistence and ability to pass through constricted spaces.
> ORGAN PHYSIOLOGY
The regular physiology of cells in living organs is closely linked with its spatial and mechanical organization.
4Dcell offers simple and representative models highlighting organ specific read-outs.
For instance, 4Dcell Micropatterns induce striation of cardiomyocyte leading to standardized beating properties and internal organization.
> RARE DISEASES
Rare diseases are often linked to cell mechanics or cell organization disorders.
The 4Dcell technologies highlight alterations like these and one can measure molecular modifications more easily than with other models.
For instance, cell nucleus healing in laminopathy is evaluated using Cell confinement by the observation of lamina reconstruction as a read-out.
> 4DCELL AT BIOFIT
Very interesting opportunities
With the highest attending rate of academics, TTOs and research institutions, BioFIT is the place where academia-industry collaborations get started. Very interesting opportunities in perspective on 4Dcell “SmartMicroOrgans” innovative in vitro models.