SOLUTIONS TO DEVELOP
ORGAN-IN-WELL MODELS
NEW BREAKTHROUGH READ-OUTS
4DCell brings biophysics and microfabrication together to design and provide cell culture systems dedicated to in vitro assays.
Using innovative technologies 4Dcell reproduces the natural cell constraints by controlling the cell micro-environment in vitro.
4Dcell R&D experts discuss with your scientific team about your current cell model limitations and define how we can improve it to reach new breakthrough reat-outs.
Illustration: hPSC-Cardiomyocyte on 4Dell line micropatterns imaged by fluorescence microscopy.
In collaboration with Dussaud S., Jouve C., Hulot J.S., 2018, INSERM, PARCC.
CANCER RESEARCH
Cell mechanics or cell organization are key parameters for cancer development and metastasis.
The FMPsTM enable us to better control these parameters and offer new read-outs to decipher cancer progression and invasiveness.
For instance, spindle assembly disorders of cancerous cells are easily assessed via FMPsTM Cell confinement technology.
IMMUNOLOGY
Sensing and migration in the tissues is the basis of the immune system functionning.
FMPsTM are the best tools to quantitfy immune activities such as cell migration, cell-interaction, nucleus plasticity, among others.
For instance, FMPsTMMicrochannels can quantify leukocyte extravasation ability, with read-outs such as: cell speed, persistence and ability to pass through constricted spaces.
ORGAN PHYSIOLOGY
The regular physiology of cells in living organs is closely linked with its spatial and mechanical organization.
FMPsTM offer simple and representative models highlighting organ specific read-outs.
For instance, FMPsTM Micropatterns induce striation of cardiomyocyte leading to standardized beating properties and internal organization.
RARE DISEASES
Rare diseases are often linked to cell mechanics or cell organization disorders.
The FMPsTM highlight alterations like these and one can measure molecular modifications more easily than with other models.
For instance, cell nucleus healing in laminopathy is evaluated using FMPsTM Cell confinement by the observation of lamina reconstruction as a read-out.
4Dcell was also nominated for the 2018 national competition for innovative technologies company creation.
4Dcell is one of the 2018 laureates of the most important french scientific entrepreneur network.
Scientipole is partner in 4Dcell success with a loan to achieve the first operational prototype of the new generation of multiwell plates for 3D cell culture.
THEY TRUST US
