CUSTOMIZED ORGAN-IN-A-WELL MODELS FOR IN VITRO ASSAYS

 

NEW BREAKTHROUGH READ-OUTS

 

4DCell brings biophysics and microfabrication together to design and provide cell culture systems dedicated to in vitro assays. Using innovative technologies 4Dcell reproduces the natural cell constraints by controlling the cell micro-environment in vitro. 

DRUG SCREENING ACTIVITIES

EXAMPLES OF APPLICATIONS

CANCER RESEARCH

Cell mechanics or cell organization are key parameters for cancer development and metastasis.

The FMPs^TM enable us to better control these parameters and offer new read-outs to decipher cancer progression and invasiveness.

For instance, spindle assembly disorders of cancerous cells are easily assessed via FMPs^TM Cell confinement technology.

IMMUNOLOGY

Sensing and migration in the tissues is the basis of the immune system functionning.

FMPs^TM are the best tools to quantitfy immune activities such as cell migration, cell-interaction, nucleus plasticity, among others.

For instance, FMPs^TMMicrochannels can quantify leukocyte extravasation ability, with read-outs such as: cell speed, persistence and ability to pass through constricted spaces.

ORGAN PHYSIOLOGY

The regular physiology of cells in living organs is closely linked with its spatial and mechanical organization.

FMPs^TM offer simple and representative models highlighting organ specific read-outs.

For instance, FMPs^TM Micropatterns induce striation of cardiomyocyte leading to standardized beating properties and internal organization.

RARE DISEASES

Rare diseases are often linked to cell mechanics or cell organization disorders.

The FMPs^TM highlight alterations like these and one can measure molecular modifications more easily than with other models.

For instance, cell nucleus healing in laminopathy is evaluated using FMPs^TM Cell confinement by the observation of lamina reconstruction as a read-out.