3D CELL-BASED ASSAYS

NEW BREAKTHROUGH READ-OUTS

HTS/HCS COMPATIBLE

CANCER RESEARCH

Cell mechanics or cell organization are key parameters for cancer development and metastasis.

The FMPs^TM enable us to better control these parameters and offer new read-outs to decipher cancer progression and invasiveness. For instance, spindle assembly disorders of cancerous cells are easily assessed via FMPs^TM Cell confinement technology.

IMMUNOLOGY

Sensing and migration in the tissues is the basis of the immune system functionning.

FMPs^TM are the best tools to quantitfy immune activities such as cell migration, cell-interaction, nucleus plasticity, among others. For instance, FMPs^TMMicrochannels can quantify leukocyte extravasation ability, with read-outs such as: cell speed, persistence and ability to pass through constricted spaces.

ORGAN PHYSIOLOGY

The regular physiology of cells in living organs is closely linked with its spatial and mechanical organization.

FMPs^TM offer simple and representative models highlighting organ specific read-outs. For instance, FMPs^TM Micropatterns induce striation of cardiomyocyte leading to standardized beating properties and internal organization.

RARE DISEASES

Rare diseases are often linked to cell mechanics or cell organization disorders.

The FMPs^TM highlight alterations like these and one can measure molecular modifications more easily than with other models. For instance, cell nucleus healing in laminopathy is evaluated using FMPs^TM Cell confinement by the observation of lamina reconstruction as a read-out.

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