SMART CONTROL OF THE CELL

 

MICROENVIRONMENT

 

BIOENGINEERED IN VITRO ASSAYS

 

OUR PRODUCTS

2D and “2,5D” bioengineered cell culture consumables to control the cell microenvironment

4Dcell is a pionneer in the development and commercialization of microfabricated systems dedicated to the control of the cell microenvironment. Our team brings all its expertise to help you in your experiments, allowing you creating the ultimate cell microenvironment.

HOW CAN 4DCELL BRING BIOENGINEERING TO OPTIMIZE YOUR IN VITRO ASSAYS?

EXAMPLES OF APPLICATIONS

oncology

CANCER RESEARCH

Cell mechanics or cell organization are key parameters for cancer development and metastasis.

4Dcell enables to better control these parameters and offer new read-outs to decipher cancer progression and invasiveness.

For instance, spindle assembly disorders of cancerous cells are easily assessed via Cell confinement technology.

immunology

IMMUNOLOGY

Sensing and migration in the tissues is the basis of the immune system functionning.

4Dcell technologies are the best tools to quantitfy immune activities such as cell migration, cell-interaction, nucleus plasticity, among others.

For instance, 4Dcell Microchannels can quantify leukocyte extravasation ability, with read-outs such as: cell speed, persistence and ability to pass through constricted spaces.

line patterned cardiomyocytes

ORGAN PHYSIOLOGY

The regular physiology of cells in living organs is closely linked with its spatial and mechanical organization.

4Dcell offers simple and representative models highlighting organ specific read-outs.

For instance, 4Dcell Micropatterns induce striation of cardiomyocyte leading to standardized beating properties and internal organization.

rare disease

RARE DISEASES

Rare diseases are often linked to cell mechanics or cell organization disorders.

The 4Dcell technologies highlight alterations like these and one can measure molecular modifications more easily than with other models.

For instance, cell nucleus healing in laminopathy is evaluated using Cell confinement by the observation of lamina reconstruction as a read-out.

European commission supports 4Dcell in innovative research

ERC Poc program optimized the development of cell confinement

iLAB

4Dcell was also nominated for the i-Lab 2018 national competition for innovative technologies company creation.

4Dcell is one of the 2018 laureates of the most important french entrepreneur network.
Reseau Entreprendre Paris is partner in 4Dcell success with a loan to achieve the first operational prototype of the new generation of multiwell plates for 3D cell culture.

THEY TRUST US