OUR PRODUCTS
2D and “2.5D” bioengineered cell culture consumables to control the cell microenvironment
4Dcell is a pioneer in the development and commercialization of microfabricated systems dedicated to the control of the cell microenvironment.
Homogenous confinement of cells between two parallel planes to a defined micrometer height with sub micrometer resolution.
Microfluidic devices to study cell migration under controlled conditions mimicking their physiological environment.
Gels with tunable stiffness that can be molded to replicate the exact 3D environment your cells need to grow.
APPLICATIONS
A widespread range of applications for 4Dcell 2D and ”2.5D” tools, covering the hot topics of the moment in cell biology. 4Dcell technologies can be applied to several cell types and enable the acquisition of distinct readouts.
BY CELL TYPE
Immune cells
Improve tracking and imaging of immune cells, imitate phagocytosis and improve the phenotypes of your cells
Cardiomyocytes
Improve differentiation of neonatal and iPSC-derived cardiomyocytes, quantify contractility
Muscle cells
Improve differentiation of myoblasts to myotubes, quantify contractility and imitate the neuromuscular junction
Hepatocytes
Improve cell-cell interaction and imaging
Neurons
Improve neuronal network formation and imitate the neuromuscular junction
Cancer cells
Observe cancer cell migration in conditions that imitate metastasis, and quantify aggressiveness and contractility
Fibroblasts
Trigger migration using click chemistry, quantify cell contractility
Stem cells
Manipulate stem cell differentiation using cell patterning and substrate stiffness
Other cell types
Assays for bone cells, adipocytes, endothelial cells, ciliated cells, and other general applications
BY READOUT
Cell migration
Confine migration in 2D or 3D to facilitate tracking, mimic migration through tissues, and study chemotaxis
Cell organization & phenotype
Restrict cell adhesion in 2D to promote differentiation or improve reproducibility of your assays
Cell differentiation
Drive cell differentiation by controlling substrate stiffness and confining cells in 2D and 3D
Cell-cell interaction
Confine your cells in 2D to better image interaction between one or more cell type
Cell contractility
Quantify the contractility of cells on gels or micropillars
Cell membrane events
Mimic phagocytosis, Observe endo- or exocytosis, and generate exosomes
Mitosis & nucleus related events
Quantify nucleus fragility and the ability of the cell to perform mitosis under stress
Co-cultures
Analysis of the cell-cell contact by click chemistry technology
Cell volume
Accurately measure the volume of your cells
Other readouts
Spheroid formation, blood vessel formation, neuromuscular junction and more
LATEST UPDATES
Observing cells by time-lapse microscopy
Using 4Dcell micropatterns, cells are cultured on substrate patterned with adherent domains of predefined geometric features in a standard glass-bottom Petri dish that enables to observe them by time-lapse microscopy. Read more …
> LAMELLIPODIA AND FILOPODIA ASSAY
Analyzing events occuring during membrane protrusion
Using 4Dcell squared micropatterns, lamellipodia tend to go at the corner of the cells patterned making easier their behavior study. Read more …
Fabrication of mimetic nanovesicles
Using 4Dcell microchannels, cells are forced through hydrophilic microchannels generating artificial nanovesicles. These nanovesicles are derived from cell membranes and contain intact membrane proteins. Read more …
> 4DCELL AT BIOFIT
Very interesting opportunities
With the highest attending rate of academics, TTOs and research institutions, BioFIT is the place where academia-industry collaborations get started. Very interesting opportunities in perspective on 4Dcell “SmartMicroOrgans” innovative in vitro models.
THEY TRUST US
