> COVERSLIP COATED WITH MICROSTRUCTURED GEL

Control the shape and the stiffness to replicate the in vivo environment

Substrates where cells are cultured contain soft or rigid microstructures in the form of open microchannels or wells. Therefore, cells can be confined in 3D environments or on the top of substrates that resembles their in vivo stiffness and that contains these topographical features.

 

> Ready to use

Plate your cells directly

 

> A wide range of stiffness available

From very hard (200 kPa) to very soft (1 kPa)

 

> A wide range of 3D designs 

Grooves, wells, lines, etc.

Several structures available (grooves, square wells, round wells, lines)

Depth can be chosen (5, 10, 15 µm)

Stiffness of the substrate can be chosen from very hard (500 kPa) to soft (< 500 Pa)

Rapid to use since cells are seeded directly on the top of features (convenient to confine non migrating cells)

Bio-functionalization with ECM proteins

Adaptable to any cell culture substrate (from Petri dishes to 96 well plates)

Compatible with high-resolution optical microscopy systems

Standard positioning of micropattern areas

> CANCER

  • Cell shape standardization

 

> ORGAN PHYSIOLOGY

  • Migration of somatic and cancer cells
  • Cell shape standardization
  • Cardiomyocyte beating properties
  • Neural network
  • Detection of bile canaliculi in hepatocytes
  • Tissue geometry mimicry

 

> RARE DISEASES

  • Cell nucleus integrity
  • Nuclear plasticity
  • Neural network

 

> FUNDAMENTAL RESEARCH

  • Cell shape standardization
  • Standardized connectivity between neurons

 

> BIOMOLECULAR IN VITRO MODELS

  • Spatial autoorganization of macromolecules (at the microscale)