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5000+ ORGANOIDS

5000+ ORGANOIDS

5000+ ORGANOIDS

4DCELL CARDIAC EXPERTISE CENTER

3D HUMAN HEART MODELS FOR SELECTING THE RIGHT MOLECULES

Scientifique utilisant un microscope

Human-relevant cardiac safety, toxicology, and efficacy testing using advanced functional and molecular assays.

Our cardiac CRO services support early discovery through lead optimization, enabling confident decision-making with predictive human data.​

 

Key applications

  • Cardiotoxicity and pro-arrhythmia risk assessment

  • Functional efficacy and mechanism-of-action studies

  • Lead compound ranking and de-risking

Cardiac Safety, Toxicology & Efficacy Assays

​Acute Cardiac Contractility Assay

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Rapid evaluation of compound effects on cardiac contractile function using phase-contrast video analysis in human cardiomyocytes.

Designed for high-throughput cardiotoxicity screening and efficacy ranking.

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Key readouts

  • Contractility amplitude and strength

  • Beat rate and rhythm stability

  • Contraction and relaxation kinetics

  • Dose–response relationships​​​​

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Cardiac Electrophysiology Assay​

(Membrane Potential Imaging)

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Human-relevant electrophysiology testing to detect electrophysiological liabilities and pro-arrhythmic risk.

Membrane-potential imaging enables sensitive detection of rate and waveform abnormalities.

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Key readouts

  • Action potential waveform features

  • Beat rate and rhythm irregularities

  • Arrhythmia-like events

  • Concentration-response effects

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Integrated Cardiac Functional Screening Panel​

(Contractility, Electrophysiology & Calcium)

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A comprehensive multi-endpoint cardiac screening platform combining mechanical, electrophysiological , and calcium handling assays in a single study. Optimized for side-by-side compound comparison.

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Key benefits

  • Unified dataset across functional modalities

  • Rapid compound ranking and liability profiling

  • Streamlined reporting and interpretation

Chronic Cardiac Contractility Assay

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Assessment of delayed and cumulative cardiotoxic effects under repeated or long-term exposure.

Ideal for identifying progressive functional liabilities missed by acute assays.

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Key readouts

  • Time-dependent contractility changes

  • Chronic exposure dose–response profiles

  • Functional stability and recovery analysis

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Calcium Transient Assay

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Quantitative analysis of intracellular calcium handling, a critical determinant of cardiac function and arrhythmia risk.

Supports mechanistic interpretation of contractility and electrophysiology findings.

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Key readouts

  • Calcium transient amplitude and frequency

  • Rise and decay kinetics

  • Beat-to-beat variability

  • Exposure–response analysis​​​

Molecular & Imagind Add-on Services

Targeted Gene Expression (qPCR)​

Mechanistic insight through targeted cardiac gene expression profiling. Custom panels include ion channels, stress markers, maturation markers, or client-defined targets.

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​Acute Cardiac Pacing (Stress Testing)​

Controlled beat-rate pacing to reveal rate-dependent cardiotoxicity and hidden functional liabilities under stress conditions.​

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Live Fluorescence Functional Characterization​

Real-time imaging of client-provided fluorescent reporters or dyes to track dynamic cellular responses during cardiac assays.​

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Transcriptome Profiling (RNA-Seq)​

Unbiased RNA-seq analysis to identify toxicity pathways, off-target effects, and mechanism-of-action signatures, integrated with functional data.

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Immunofluorescence & Structural Cardiac Imaging​

High-resolution imaging of cardiac tissue structure and molecular markers following functional testing.

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Applications

  • Sarcomeric organization

  • Stress and toxicity marker analysis

  • Structural integrity assessment​

Cardiac Cell Line Qualification Services

Cardiac Cell Line Characterization

Pre-study qualification of human cardiac cell lines to ensure robust tissue formation and reproducible functional performance.

 

Outcomes

  • Optimized seeding and culture conditions

  • Baseline contractility benchmarks

  • Reduced assay variability

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Baseline Cardiac Functional Qualification Panel

Comprehensive baseline assessment of contractility, electrophysiology, and calcium handling to qualify new cell lots, tissues, or protocols prior to screening.

Why Choose Our Cardiac CRO Services?

  • Human-relevant cardiac models

  • Multi-endpoint functional readouts

  • Flexible study design and custom endpoints

  • Direct scientific support and interpretation

DO YOU WANT TO PUSH THE LIMITS OF 3D CELL CULTURE? LET'S DISCUSS YOUR PROJECTS

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