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5000+ ORGANOIDS

5000+ ORGANOIDS

5000+ ORGANOIDS

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HYDROGELS
TUNE THE STIFFNESS OF THE CULTURE SUBSTRATE

GUIDING CELLULAR BEHAVIOR WITH PRECISION

Hydrogels are a cornerstone of in vitro cell culture, providing a tunable microenvironment that mimics the mechanical properties of native tissues.

The 4Dcell offering includes two hydrogel-coated coverslip formats that integrate seamlessly with your microscopy workflows.

The first, a simple hydrogel coverslip, pairs a glass substrate with a biocompatible matrix whose elasticity can be adjusted from a few hundred pascals to several kilopascals, perfect for probing cell adhesion, motility, and differentiation as a function of substrate stiffness.

The second, a microstructured hydrogel coverslip, retains this mechanical tunability while adding customizable microgrooves: these microscopic channels guide and align cells (neuronal axons, muscle fibers, dendrites…), control their polarization, and promote the formation of structured endothelial networks, delivering a more faithful reproduction of in vivo tissue architectures.

 

Together, these two products provide a highly reproducible, easy-to-implement platform that combines mechanical and topographical cues to accelerate your discoveries and enhance the robustness of your results.

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Easy to use

High resolution imaging

Long term cell culture

PLATE YOUR CELLS. LET THEM GROW. MEASURE.

HYDROGEL TECHNOLOGY

Cells are cultured in a 3D environment (different stiffnesses, either flat or microstructured, to mimic in vivo conditions).

  • Stiffness of the substrate can be chosen from very soft (1 kPa) to very hard (50 kPa)

  • Wide range of substrates topography available (flat, round wells, square wells, grooves, etc.)

  • The gel based substrates are ready to be used in your cell culture experiments 

  • Easy and straightforward to use, since cells are seeded directly on top of the features (convenient to confine non migrating cells)

  • Pre-coated with ECM matrix (e.g. fibronectin) 

  • Adaptable to any cell culture substrate (coverslips, Petri dishes, multiwell plates)

  • The optically transparency of the gels makes these substrates compatible with high-resolution optical microscopy systems

 

Contact us if you want a customized design.

SmartGels-scheme

Gel on coverslip principle

Microgroove-scheme

Microstructured gel principle

SMARTGELS APPLICATIONS

Cell differentiation, Cell mechanics, Cell contractility, Cell migration, Tissue geometry mimicry, 3D cell shape control, etc.

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HeLa cells seeded on microstructured gels

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Mouse embryonic fibroblasts seeded on grooves 

Domains of application

CANCER

  • Cell shape standardization

ORGAN PHYSIOLOGY

  • Migration of somatic and cancer cells

  • Cell shape standardization

  • Cardiomyocyte beating properties

  • Neural network

  • Detection of bile canaliculi in hepatocytes

  • Tissue geometry mimicry

RARE DISEASES

  • Cell nucleus integrity

  • Nuclear plasticity

  • Neural network

FUNDAMENTAL RESEARCH

  • Cell shape standardization

  • Standardized connectivity between neurons

 

BIOMOLECULAR IN VITRO MODELS

  • Spatial autoorganization of macromolecules (at the microscale)

SMARTGELS CATALOG

YOU WANT TO PUSH THE LIMITS OF 3D CELL CULTURE? LET'S DISCUSS YOUR PROJECTS

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