SmartContractility Plate - 96 well plate with hydrogel-based microwells
Why SmartContractility?
Flat cell cultures can't replicate the complex 3D architecture and contractile function of real heart and muscle tissue. The result is poor clinical translation, unpredictable drug responses, and wasted time on models that don't work.
Our SmartContractility solves this.
Our precision-engineered 3D platform creates functional, beating muscle tissues that behave like native tissue, delivering the predictive power you need and the reproducibility reviewers demand.
What Makes SmartContractility Different
- Physiologically Relevant Tissues: Cells self-organize into ring-shaped contractile tissues around a central pillar. Real sarcomere alignment. Synchronized beating. Quantifiable force generation. This is muscle tissue that actually works.
- Results in Days, Not Weeks: Functional tissues form in 3-7 days. Run experiments faster, iterate quicker, and accelerate your path to publication.
- Use 10-50x Fewer Cells: Stop burning through expensive iPSCs. Our 96-well format maximizes every precious cell, cutting reagent costs dramatically while enabling true high-throughput studies.
- Reproducibility You Can Publish: Engineered precision eliminates operator variability. Standardized protocols deliver consistent results across experiments and between labs. CV values consistently below 15%.
- Drop-In Automation Compatible: SLAS/ANSI standard format. Works with your existing liquid handlers and imaging systems. Scale from discovery to screening without changing platforms.
- AI-Powered Analysis Included: SmartX® 2.0 software analyzes brightfield videos automatically. Extract contraction amplitude, beating rate, strain, velocity, and rhythm parameters in minutes: no expensive equipment or manual tracking required.
- Crystal-Clear Imaging: Glass-bottom design works with any microscope. Perfect for confocal imaging, high-content screening, calcium imaging, and immunofluorescence.
- Long-Term Culture Stable: Maintain functional tissues for 4+ weeks. Ideal for chronic dosing studies, disease progression modeling, and maturation experiments.
Proven Applications
Drug Discovery & Development: Screen for cardiotoxicity and myotoxicity with physiological endpoints. De-risk your pipeline before clinical trials.
High-Throughput Screening: Test entire compound libraries in 96-well format with robust Z' factors and minimal cell consumption.
Disease Modeling: Create accurate models of cardiomyopathies, muscular dystrophies, and metabolic disorders using patient-derived iPSCs.
Mechanistic Research: Study muscle development, regeneration, calcium handling, and contractile dysfunction with quantifiable precision.
Therapeutic Validation: Test gene therapies, biologics, and small molecules with functional contractility as your primary endpoint.
How It Works
- Engineered Microwell Design: Our proprietary hydrogel molds create conical microwells with a central pillar. Cells naturally organize into ring-shaped tissues that wrap around the pillar.
- Real-Time Contractility Measurement: As tissues contract, pillar deformation provides direct measurement of force, amplitude, and beating parameters: no sensors or electrodes required.
- Publication-Ready Data Export quantitative data on contraction amplitude, strain, velocity, beating rate, and rhythm regularity. Statistical analysis included.
Applications
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Cardiotoxicity screening
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Drug efficacy evaluation
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In vitro disease modeling
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High-content cardiac research
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Automation & Analysis
AI Analysis with SmartX® 2.0
- Record simple brightfield videos.
- Our machine learning algorithm automatically tracks pillar movement and extracts comprehensive contractility metrics.